Mesenchymal stem cells in the bone marrow microenvironment: a double-edged sword for AML

Abstract Mesenchymal stem cells (MSCs) play a pivotal role in supporting acute myeloid leukemia (AML) cell survival, proliferation, and drug resistance through various mechanisms, including the release of soluble factors, direct cell-cell interactions, and the creation of a leukemia-supportive niche...

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Bibliographic Details
Main Authors: Mohamed J. Saadh, Nima Torabi Fard, Ahmed Hussein, Amirhossein Mirzazadeh, Mohammad Siavashi, Fatemeh SeyedMoharami, Shekoofeh Noroozi, Hamed Soleimani Samarkhazan
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Journal of Cancer Research and Clinical Oncology
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Online Access:https://doi.org/10.1007/s00432-025-06244-4
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