Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells

Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells

Niemann Pick Disease Type C (NP-C), a rare neurogenetic disease with no known cure, is caused by mutations in the cholesterol trafficking protein NPC1. Brain microvascular endothelial cells (BMEC) are thought to play a critical role in the pathogenesis of several neurodegenerative diseases; however,...

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Bibliographic Details
Main Authors: Bilal Moiz, Matthew Walls, Viviana Alpizar Vargas, Anirudh Addepalli, Callie Weber, Andrew Li, Ganesh Sriram, Alisa Morss Clyne
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Neurobiology of Disease
Subjects:
Niemann-pick disease type C
NPC1
Metabolism
Metabolic flux analysis
Systems biology
Glycolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003711
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