High glucose inhibits proliferation, migration, and osteogenic differentiation of human placenta-derived mesenchymal stem cells

High glucose inhibits proliferation, migration, and osteogenic differentiation of human placenta-derived mesenchymal stem cells

Abstract Chronic hyperglycemia is recognized as an important contributor to chronic inflammation, oxidative stress, and organ dysfunction that causes serious complications in diabetes and aging. This study investigates the effects of elevated glucose levels on human placenta-derived mesenchymal stem...

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Bibliographic Details
Main Authors: Supawadee Duangprom, Pakpoom Kheolamai, Chairat Tantrawatpan, Sirikul Manochantr
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Mesenchymal stem cells
Diabetes
Osteogenic differentiation
Placenta
Senescence
Online Access:https://doi.org/10.1038/s41598-025-06454-3
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