Enhancement of systemic and lung-localized CD4<sup>+</sup> T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain
Introduction. There is a large variety of licensed influenza vaccines worldwide, but their common limitation is rather narrow specificity and inability to protect against antigenic-drift variants of influenza virus. Therefore, optimization of immunogenic and cross-protective properties of licensed i...
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Main Authors: | Polina I. Prokopenko, Ekaterina A. Stepanova, Victoria A. Matyushenko, Alexandra Ya. Rak, Anna K. Chistyakova, Arina D. Kostromitina, Tatyana S. Kotomina, Igor V. Kudryavtsev, Artem A. Rubinstein, Alexey S. Komlev, Larisa G. Rudenko, Irina N. Isakova-Sivak |
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Format: | Article |
Language: | Russian |
Published: |
Central Research Institute for Epidemiology
2024-11-01
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Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
Subjects: | |
Online Access: | https://microbiol.crie.ru/jour/article/viewFile/18682/1518 |
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