Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review
BackgroundMigraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. The rapid progress in multi-omics technologies has provided new tools to uncover...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1452614/full |
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| author | Jiaojiao Liu Qiaosheng Ren Boxuan Du Xian Liu Yuqiu An Peichi Zhang Lexi Li Zhenhong Liu Zhenhong Liu Kegang Cao Kegang Cao |
| author_facet | Jiaojiao Liu Qiaosheng Ren Boxuan Du Xian Liu Yuqiu An Peichi Zhang Lexi Li Zhenhong Liu Zhenhong Liu Kegang Cao Kegang Cao |
| author_sort | Jiaojiao Liu |
| collection | DOAJ |
| description | BackgroundMigraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. The rapid progress in multi-omics technologies has provided new tools to uncover the intricate pathological mechanisms underlying migraine. This systematic review aims to synthesize the findings of multi-omics studies on migraine to further elucidate the complex mechanisms of disease onset, thereby laying a scientific foundation for identifying new therapeutic targets.MethodsWe conducted a comprehensive systematic review, specifically focusing on clinical observational studies that investigate various aspects of migraine through the integration of genomics, transcriptomics, proteomics, and metabolomics. Our search encompassed multiple databases including PubMed, EMBASE, the Web of Science Core Collection, the Cochrane Library, China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, the Wanfang database, and the China Biology Medicine Database to cover studies from database inception until 20 March 2024., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=470268, identifier CRD42024470268. |
| format | Article |
| id | doaj-art-b45dafc59944462c97172605b8f70e1d |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b45dafc59944462c97172605b8f70e1d2025-01-09T06:10:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14526141452614Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic reviewJiaojiao Liu0Qiaosheng Ren1Boxuan Du2Xian Liu3Yuqiu An4Peichi Zhang5Lexi Li6Zhenhong Liu7Zhenhong Liu8Kegang Cao9Kegang Cao10Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaInstitute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, ChinaBackgroundMigraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. The rapid progress in multi-omics technologies has provided new tools to uncover the intricate pathological mechanisms underlying migraine. This systematic review aims to synthesize the findings of multi-omics studies on migraine to further elucidate the complex mechanisms of disease onset, thereby laying a scientific foundation for identifying new therapeutic targets.MethodsWe conducted a comprehensive systematic review, specifically focusing on clinical observational studies that investigate various aspects of migraine through the integration of genomics, transcriptomics, proteomics, and metabolomics. Our search encompassed multiple databases including PubMed, EMBASE, the Web of Science Core Collection, the Cochrane Library, China National Knowledge Infrastructure, the Chinese Science and Technology Periodical Database, the Wanfang database, and the China Biology Medicine Database to cover studies from database inception until 20 March 2024., The scope of our review included various aspects of migraine such as ictal and interictal phases; episodic or chronic migraine; menstrual-related migraine; and migraine with or without aura (PROSPERO registration number: CRD42024470268).ResultsA total of 38 studies were ultimately included, highlighting a range of genetic variations, transcriptional abnormalities, protein function alterations, and disruptions in metabolic pathways associated with migraine.These multi-omics findings underscore the pivotal roles played by mitochondrial dysfunction, inflammatory responses, and oxidative stress in the pathophysiology of migraine.ConclusionMulti-omics approaches provide novel perspectives and tools for comprehending the intricate pathophysiology of migraine, facilitating the identification of potential biomarkers and therapeutic targets.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=470268, identifier CRD42024470268.https://www.frontiersin.org/articles/10.3389/fphar.2024.1452614/fullmulti-omicsmigraineinflammationoxidative stressmitochondrial dysfunctionsystematic review |
| spellingShingle | Jiaojiao Liu Qiaosheng Ren Boxuan Du Xian Liu Yuqiu An Peichi Zhang Lexi Li Zhenhong Liu Zhenhong Liu Kegang Cao Kegang Cao Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review Frontiers in Pharmacology multi-omics migraine inflammation oxidative stress mitochondrial dysfunction systematic review |
| title | Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review |
| title_full | Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review |
| title_fullStr | Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review |
| title_full_unstemmed | Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review |
| title_short | Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review |
| title_sort | multi omics approaches to deciphering complex pathological mechanisms of migraine a systematic review |
| topic | multi-omics migraine inflammation oxidative stress mitochondrial dysfunction systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1452614/full |
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