Assessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional study
Abstract Background Systemic Lupus Erythematosus (SLE) affects all organ systems. As a result, fat intake and sedentary life are evident in the modern world. The prevalence of metabolic syndrome, with its components, increased, leading to increased mortality. We aimed to investigate the prevalence o...
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BMC
2025-01-01
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| Series: | BMC Rheumatology |
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| Online Access: | https://doi.org/10.1186/s41927-024-00453-z |
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| author | Noura Mallouhi Ahmad Nabil Alhouri Naram Khalayli Hasan Nabil Alhouri Mayssoun Kudsi Younes Kabalan |
| author_facet | Noura Mallouhi Ahmad Nabil Alhouri Naram Khalayli Hasan Nabil Alhouri Mayssoun Kudsi Younes Kabalan |
| author_sort | Noura Mallouhi |
| collection | DOAJ |
| description | Abstract Background Systemic Lupus Erythematosus (SLE) affects all organ systems. As a result, fat intake and sedentary life are evident in the modern world. The prevalence of metabolic syndrome, with its components, increased, leading to increased mortality. We aimed to investigate the prevalence of metabolic syndrome in SLE and its relationship with disease activity. Methods A cross-sectional study was conducted on 70 SLE patients at Al Mouwasat University Hospitals in Damascus, Syria, between November 2021 and November 2022. The patients were divided into two groups based on the presence or absence of metabolic syndrome. The SLE Disease Activity Index (SLEDAI) was assessed in each group and compared with different disease parameters. Results Out of the 70 patients, 65 were females. The mean age was 32.19 ± 7.15 years, and the mean disease duration was 4.4 ± 2.96 years. Metabolic syndrome was found in 32 patients (45.7%). Metabolic syndrome in SLE patients was associated with a higher disease activity index, older age, delayed age at first diagnosis, longer disease duration, higher frequency of renal involvement, and use of cyclophosphamide. Conclusion Our study highlights the importance of evaluating and treating metabolic syndrome and its components in patients with SLE, as it may play a role in controlling disease activity. We recommend conducting larger studies in the future to overcome the limitations of this research, such as including a larger number of patients, conducting multicenter studies to generalize the results, and including a healthy control group. |
| format | Article |
| id | doaj-art-b44de12aa252411f97968c48784d9385 |
| institution | Kabale University |
| issn | 2520-1026 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Rheumatology |
| spelling | doaj-art-b44de12aa252411f97968c48784d93852025-01-05T12:49:40ZengBMCBMC Rheumatology2520-10262025-01-01911710.1186/s41927-024-00453-zAssessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional studyNoura Mallouhi0Ahmad Nabil Alhouri1Naram Khalayli2Hasan Nabil Alhouri3Mayssoun Kudsi4Younes Kabalan5Rheumatology Department, Damascus UniversityDiagnostic Radiology Department, Damascus UniversityPsychiatry Department, Damascus UniversityInternal Medicine Department, Damascus UniversityRheumatology Department, Damascus UniversityEndocrinology Department, Damascus UniversityAbstract Background Systemic Lupus Erythematosus (SLE) affects all organ systems. As a result, fat intake and sedentary life are evident in the modern world. The prevalence of metabolic syndrome, with its components, increased, leading to increased mortality. We aimed to investigate the prevalence of metabolic syndrome in SLE and its relationship with disease activity. Methods A cross-sectional study was conducted on 70 SLE patients at Al Mouwasat University Hospitals in Damascus, Syria, between November 2021 and November 2022. The patients were divided into two groups based on the presence or absence of metabolic syndrome. The SLE Disease Activity Index (SLEDAI) was assessed in each group and compared with different disease parameters. Results Out of the 70 patients, 65 were females. The mean age was 32.19 ± 7.15 years, and the mean disease duration was 4.4 ± 2.96 years. Metabolic syndrome was found in 32 patients (45.7%). Metabolic syndrome in SLE patients was associated with a higher disease activity index, older age, delayed age at first diagnosis, longer disease duration, higher frequency of renal involvement, and use of cyclophosphamide. Conclusion Our study highlights the importance of evaluating and treating metabolic syndrome and its components in patients with SLE, as it may play a role in controlling disease activity. We recommend conducting larger studies in the future to overcome the limitations of this research, such as including a larger number of patients, conducting multicenter studies to generalize the results, and including a healthy control group.https://doi.org/10.1186/s41927-024-00453-zSystemic lupus erythematosusMetabolic syndromePrevalenceSyria |
| spellingShingle | Noura Mallouhi Ahmad Nabil Alhouri Naram Khalayli Hasan Nabil Alhouri Mayssoun Kudsi Younes Kabalan Assessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional study BMC Rheumatology Systemic lupus erythematosus Metabolic syndrome Prevalence Syria |
| title | Assessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional study |
| title_full | Assessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional study |
| title_fullStr | Assessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional study |
| title_full_unstemmed | Assessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional study |
| title_short | Assessing the relation between systemic lupus erythematosus and metabolic syndrome in Syria: a cross-sectional study |
| title_sort | assessing the relation between systemic lupus erythematosus and metabolic syndrome in syria a cross sectional study |
| topic | Systemic lupus erythematosus Metabolic syndrome Prevalence Syria |
| url | https://doi.org/10.1186/s41927-024-00453-z |
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