Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling

Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling

Abstract Crosstalk mechanisms have not been studied as thoroughly as individual signaling pathways. We exploit experimental and computational approaches to reveal how a concordant interplay between the insulin and epidermal growth factor (EGF) signaling networks can potentiate mitogenic signaling. I...

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Bibliographic Details
Main Authors: Nikolay Borisov, Edita Aksamitiene, Anatoly Kiyatkin, Stefan Legewie, Jan Berkhout, Thomas Maiwald, Nikolai P Kaimachnikov, Jens Timmer, Jan B Hoek, Boris N Kholodenko
Format: Article
Language:English
Published: Springer Nature 2009-04-01
Series:Molecular Systems Biology
Subjects:
computational modeling
crosstalk
epidermal growth factor receptor
insulin receptor
networks
Online Access:https://doi.org/10.1038/msb.2009.19
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https://doi.org/10.1038/msb.2009.19

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