Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females

Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females

Abstract Background Skeletal muscle atrophy during cancer-induced cachexia remains a significant challenge in cancer management. Mitochondrial defects precede muscle mass and functional losses in models of cancer cachexia (CC). We hypothesized targeting Opa1—a key regulator of mitochondrial fusion—c...

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Main Authors: Francielly Morena, Seongkyun Lim, Ana Regina Cabrera, Toby L. Chambers, Pieter J. Koopmans, Stavroula Tsitkanou, Sabin Khadgi, Calvin Peterson, Eleanor R. Schrems, Ruqaiza Muhyudin, Sepideh Shakeri, Kevin Zhao, Devan Mishra, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Lewis Lung Carcinoma
BGP-15
OPA1
Mitochondrial dynamics
Muscle contractility
Online Access:https://doi.org/10.1186/s12885-025-14630-x
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https://doi.org/10.1186/s12885-025-14630-x

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