Promoter demethylation of cerebellin 2 by ten-eleven translocation 3 contributes to peripheral sensitization in trigeminal neuropathic pain of mice

Promoter demethylation of cerebellin 2 by ten-eleven translocation 3 contributes to peripheral sensitization in trigeminal neuropathic pain of mice

Abstract Background Chronic neuropathic pain involves complex molecular adaptations, and emerging evidence indicates that cerebellins (CBLNs) play a role in sensory processing. This study investigates the role of CBLN2 in trigeminal neuropathic pain (TNP) and examines its regulation through epigenet...

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Bibliographic Details
Main Authors: Xin-Ying Guan, Bao-Tong Yuan, Meng-Na Li, Tian Wang, Lin-Peng Zhu, Si-Yuan Song, Lu-Lu Ji, Yong-Jing Gao, Ling-Jie Ma
Format: Article
Language:English
Published: BMC 2025-07-01
Series:The Journal of Headache and Pain
Subjects:
CBLN2
TET3
ERK
Neuronal excitability
Neuroinflammation
Trigeminal neuropathic pain
Online Access:https://doi.org/10.1186/s10194-025-02093-1
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https://doi.org/10.1186/s10194-025-02093-1

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