Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment

Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment

Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma (MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other cells in the tumor microenvironment (TME), such as myeloid cells, possess functional antiviral pathways. In this...

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Main Authors: Camille Chatelain, Laurine Berland, Marion Grard, Nicolas Jouand, Judith Fresquet, Joëlle Nader, Ugo Hirigoyen, Tacien Petithomme, Chantal Combredet, Elvire Pons-Tostivint, Delphine Fradin, Lucas Treps, Christophe Blanquart, Nicolas Boisgerault, Frédéric Tangy, Jean-François Fonteneau
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Measles virus
mesothelioma
oncolytic immunotherapy
tumor associated macrophages
type I interferon
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2377830
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2377830

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