Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression

Abstract Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti‐cancer treatment approach, yet with low response rates. The extracellular matrix, in particular tenascin‐C, may generate barriers for TIL. To investigate this possibility, we use...

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Main Authors: Devadarssen Murdamoothoo, Zhen Sun, Alev Yilmaz, Gilles Riegel, Chérine Abou‐Faycal, Claire Deligne, Ines Velazquez‐Quesada, William Erne, Marine Nascimento, Matthias Mörgelin, Gérard Cremel, Nicodème Paul, Raphael Carapito, Romain Veber, Hélène Dumortier, Jingping Yuan, Kim S Midwood, Thomas Loustau, Gertraud Orend
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
CD8 tumor infiltrating lymphocytes
CXCL12
extracellular matrix
tenascin‐C
Tumor immune microenvironment
Online Access:https://doi.org/10.15252/emmm.202013270
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https://doi.org/10.15252/emmm.202013270

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