Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro

Palmitate enhances MSC immunomodulation of human macrophages via the ceramide/CCL2 axis in vitro

Abstract Background The immunomodulatory function of human mesenchymal stromal cells (MSCs) strongly depends on external factors; such as cytokines and other signalling molecules encountered in the disease microenvironment. An insufficiently inflammatory environment can fail to activate MSCs, and ce...

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Main Authors: Courteney Tunstead, Laura M. Bitterlich, James A. Ankrum, Andrew E. Hogan, Karen English
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Online Access:https://doi.org/10.1186/s13287-025-04536-7
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