Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor
The prevalence of obesity has increased and is a health concern worldwide. Due to the concerns regarding synthetic anti-obesity treatments, nowadays natural products become a trend. Previous studies proved that there is a potential to use marine algae as anti-obesity agents. Therefore, in this study...
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| Format: | Article |
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Tsinghua University Press
2024-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250136 |
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| author | Hyo-Geun Lee H.H.A.C.K. Jayawardhana Fengqi Yang D.P. Nagahawaththa N.M. Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon Min-Cheol Kang |
| author_facet | Hyo-Geun Lee H.H.A.C.K. Jayawardhana Fengqi Yang D.P. Nagahawaththa N.M. Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon Min-Cheol Kang |
| author_sort | Hyo-Geun Lee |
| collection | DOAJ |
| description | The prevalence of obesity has increased and is a health concern worldwide. Due to the concerns regarding synthetic anti-obesity treatments, nowadays natural products become a trend. Previous studies proved that there is a potential to use marine algae as anti-obesity agents. Therefore, in this study, the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii (STAC) and its fucoidan fractions (STAFs) on 3T3-L1 cells and high-fat diet (HFD)-induced obese mice were investigated. According to the results, the STAF3, showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 cells. Furthermore, oral supplementation with STAC significantly declined gain in body weight and fat weight, and serum lipid contents in an HFD-induced obesity mouse model. Structural and chemical characterizations demonstrated that purified STAF3 has consistent surface morphology and small particle size, with similar structural characteristics as commercial fucoidan. Together, these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity. |
| format | Article |
| id | doaj-art-b383581887c54ccea9032bfa5647a2a1 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-b383581887c54ccea9032bfa5647a2a12025-01-10T06:54:23ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-05-011331608161610.26599/FSHW.2022.9250136Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factorHyo-Geun Lee0H.H.A.C.K. Jayawardhana1Fengqi Yang2D.P. Nagahawaththa3N.M. Liyanage4Kyung-Mo Song5Yun-Sang Choi6Seung-Hong Lee7You-Jin Jeon8Min-Cheol Kang9Department of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaResearch Group of Food Processing, Korea Food Research Institute, Wanju 55365, Republic of KoreaResearch Group of Food Processing, Korea Food Research Institute, Wanju 55365, Republic of KoreaDepartment of Pharmoceutical Engineering, Soonchunhyang University, Asan 31538, Republic of KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Republic of KoreaResearch Group of Food Processing, Korea Food Research Institute, Wanju 55365, Republic of KoreaThe prevalence of obesity has increased and is a health concern worldwide. Due to the concerns regarding synthetic anti-obesity treatments, nowadays natural products become a trend. Previous studies proved that there is a potential to use marine algae as anti-obesity agents. Therefore, in this study, the lipid inhibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thunbergii (STAC) and its fucoidan fractions (STAFs) on 3T3-L1 cells and high-fat diet (HFD)-induced obese mice were investigated. According to the results, the STAF3, showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 cells. Furthermore, oral supplementation with STAC significantly declined gain in body weight and fat weight, and serum lipid contents in an HFD-induced obesity mouse model. Structural and chemical characterizations demonstrated that purified STAF3 has consistent surface morphology and small particle size, with similar structural characteristics as commercial fucoidan. Together, these results indicate that STAC and purified STAF3 from Sargassum thunbergia is a potent source to develop as ananti-obesity agents or functional food products to counter obesity.https://www.sciopen.com/article/10.26599/FSHW.2022.9250136sargassum thunbergiifucoidananti-obesityanti-steatosis |
| spellingShingle | Hyo-Geun Lee H.H.A.C.K. Jayawardhana Fengqi Yang D.P. Nagahawaththa N.M. Liyanage Kyung-Mo Song Yun-Sang Choi Seung-Hong Lee You-Jin Jeon Min-Cheol Kang Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor Food Science and Human Wellness sargassum thunbergii fucoidan anti-obesity anti-steatosis |
| title | Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor |
| title_full | Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor |
| title_fullStr | Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor |
| title_full_unstemmed | Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor |
| title_short | Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor |
| title_sort | anti obesity effects of fucoidan from sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor |
| topic | sargassum thunbergii fucoidan anti-obesity anti-steatosis |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250136 |
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