TCF12 and LncRNA MALAT1 Cooperatively Harness High Cyclin D1 but Low β-Catenin Gene Expression to Exacerbate Colorectal Cancer Prognosis Independently of Metastasis

TCF12 and LncRNA MALAT1 Cooperatively Harness High Cyclin D1 but Low β-Catenin Gene Expression to Exacerbate Colorectal Cancer Prognosis Independently of Metastasis

Metastasis is a well-known factor worsening colorectal cancer (CRC) prognosis, but mortality mechanisms in non-metastatic patients with poor outcomes are less understood. TCF12 is a transcription factor that can be physically associated with the long non-coding RNA MALAT1, creating an alliance with...

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Main Authors: Chia-Ming Wu, Chung-Hsing Chen, Kuo-Wang Tsai, Mei-Chen Tan, Fang-Yu Tsai, Shih-Sheng Jiang, Shang-Hung Chen, Wei-Shone Chen, Horng-Dar Wang, Tze-Sing Huang
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Cells
Subjects:
TCF12
MALAT1
WNT pathway
β-catenin
cyclin D1
Online Access:https://www.mdpi.com/2073-4409/13/24/2035
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https://www.mdpi.com/2073-4409/13/24/2035

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