Immune-checkpoint HLA-G gene polymorphisms, 3’-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population

Immune-checkpoint HLA-G gene polymorphisms, 3’-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population

BackgroundHuman leukocyte antigen-G (HLA-G) is a cancer-associated immune checkpoint protein implicated in tumor-driven immune escape mechanisms. This study was undertaken to determine genetic variations at the 3’-UTR of the HLA-G gene that may alter its expression, identify risk alleles and genotyp...

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Bibliographic Details
Main Authors: Neeti Nadda, Renu Yadav, Neelanjana Roy, Nita Singh, Sonu Kumar, Shashi Bala Paul, Shivanand Gamanagatti, Anoop Saraya, Shalimar, Baibaswata Nayak
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
HLA-G
HCC
genetic association
SNPs (single nucleotide polymorphism)
therapeutic response
UTR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1459749/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1459749/full

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