Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma

Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma

Abstract Despite the recent successes of immune checkpoint inhibitors (ICIs) in treating advanced melanoma, durable clinical responses still remain limited. To boost immune responses, agents that target immune regulators, such as the Stimulator of Interferon Genes (STING) agonist cyclic GMP‐AMP (cGA...

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Main Authors: Sina Khorsandi, Kristin Huntoon, Yifan Wang, Adam Woodward, Abin Antony, Connor Endsley, Nazia Hafeez, Jared L. Edwards, Nicole McCuen, Prasanna G. Alluri, Betty Y.S. Kim, Wen Jiang, Jacques Lux
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
cancer therapy
drug delivery
immunotherapy
microbubbles
sting pathway
ultrasound
Online Access:https://doi.org/10.1002/advs.202416596
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https://doi.org/10.1002/advs.202416596

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