CAR’TCR-T cells co-expressing CD33-CAR and dNPM1-TCR as superior dual-targeting approach for AML treatment

CAR’TCR-T cells co-expressing CD33-CAR and dNPM1-TCR as superior dual-targeting approach for AML treatment

Acute myeloid leukemia (AML), a fast-progressing hematological malignancy affecting myeloid cells, is typically treated with chemotherapy or hematopoietic stem cell transplantation. However, approximately half of the patients face relapses and 5-year survival rates are poor. With the goal to facilit...

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Bibliographic Details
Main Authors: Karin Teppert, Isabella Elias Yonezawa Ogusuku, Caroline Brandes, Vera Herbel, Nora Winter, Niels Werchau, Svetlana Khorkova, Christian Wöhle, Nojan Jelveh, Kevin Bisdorf, Boris Engels, Thomas Schaser, Kathleen Anders, Annette Künkele, Dominik Lock
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
Immunotherapy
adoptive T cell therapy
chimeric antigen receptor
T cell receptor
dual-specificity
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000390
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