The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study
Abstract Background Major depressive disorder (MDD) is a recurrent and persistent mental illness. However, there is a lack of research that distinguishes the severity of comorbid anxiety disorders in MDD, and insufficient evidence exists regarding the prevalence of MDD patients with comorbid moderat...
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2025-01-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-025-06472-5 |
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| author | Lina Ren Yeqing Dong Xiaojing Zhou Chuhao Zhang Jiajia Gao Lulu Li Xiao Zhang Min Zeng Guoshuai Luo Xiangyang Zhang |
| author_facet | Lina Ren Yeqing Dong Xiaojing Zhou Chuhao Zhang Jiajia Gao Lulu Li Xiao Zhang Min Zeng Guoshuai Luo Xiangyang Zhang |
| author_sort | Lina Ren |
| collection | DOAJ |
| description | Abstract Background Major depressive disorder (MDD) is a recurrent and persistent mental illness. However, there is a lack of research that distinguishes the severity of comorbid anxiety disorders in MDD, and insufficient evidence exists regarding the prevalence of MDD patients with comorbid moderate-to-severe anxiety in the Chinese population. Methods The study included 1718 MDD patients (894 with moderate-to-severe anxiety symptoms and 824 without moderate-to-severe anxiety symptoms). Clinical symptoms and development were assessed using the Hamilton Depression Rating Scale-17 (HAMD-17), Hamilton Anxiety Rating Scale-14 (HAMA-14), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI). The blood pressure and thyroid hormone levels were measured. Results We found that the incidence of MDD patients with moderate-to-severe anxiety symptoms was 52.04%. The prevalence of recent suicide attempts in MDD comorbid moderate-to-severe anxiety patients was 31.8%, which was 4.24 times higher than that in patients without moderate-to-severe anxiety. Additionally, suicide attempters had elevated levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), thyroid peroxidases antibody (TPOAb), systolic blood pressure (SBP), and diastolic blood pressure (DBP) compared to non-suicide attempters. We further identified CGI score, TSH, TPOAb, and DBP as influential factors for recent suicide attempts in MDD individuals who had moderate-to-severe anxiety symptoms. These indexes could distinguish between suicide attempts and non-suicide attempts in MDD patients with moderate-to-severe anxiety symptoms. Conclusions Our findings mainly indicated a high prevalence of recent suicide attempts in MDD patients with moderate-to-severe anxiety. Several clinical correlates, thyroid hormones, and blood pressure might contribute to recent suicide attempts in MDD patients with moderate-to-severe anxiety symptoms. |
| format | Article |
| id | doaj-art-b29a50ae62754a1a87982e961702e86d |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-b29a50ae62754a1a87982e961702e86d2025-01-12T12:34:32ZengBMCBMC Psychiatry1471-244X2025-01-012511810.1186/s12888-025-06472-5The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional studyLina Ren0Yeqing Dong1Xiaojing Zhou2Chuhao Zhang3Jiajia Gao4Lulu Li5Xiao Zhang6Min Zeng7Guoshuai Luo8Xiangyang Zhang9Department of Psychiatry, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityDepartment of Psychiatry, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Psychiatry, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityHefei Fourth People’s Hospital, Anhui Mental Health Center, Affiliated Mental Health Center of Anhui Medical UniversityAbstract Background Major depressive disorder (MDD) is a recurrent and persistent mental illness. However, there is a lack of research that distinguishes the severity of comorbid anxiety disorders in MDD, and insufficient evidence exists regarding the prevalence of MDD patients with comorbid moderate-to-severe anxiety in the Chinese population. Methods The study included 1718 MDD patients (894 with moderate-to-severe anxiety symptoms and 824 without moderate-to-severe anxiety symptoms). Clinical symptoms and development were assessed using the Hamilton Depression Rating Scale-17 (HAMD-17), Hamilton Anxiety Rating Scale-14 (HAMA-14), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI). The blood pressure and thyroid hormone levels were measured. Results We found that the incidence of MDD patients with moderate-to-severe anxiety symptoms was 52.04%. The prevalence of recent suicide attempts in MDD comorbid moderate-to-severe anxiety patients was 31.8%, which was 4.24 times higher than that in patients without moderate-to-severe anxiety. Additionally, suicide attempters had elevated levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), thyroid peroxidases antibody (TPOAb), systolic blood pressure (SBP), and diastolic blood pressure (DBP) compared to non-suicide attempters. We further identified CGI score, TSH, TPOAb, and DBP as influential factors for recent suicide attempts in MDD individuals who had moderate-to-severe anxiety symptoms. These indexes could distinguish between suicide attempts and non-suicide attempts in MDD patients with moderate-to-severe anxiety symptoms. Conclusions Our findings mainly indicated a high prevalence of recent suicide attempts in MDD patients with moderate-to-severe anxiety. Several clinical correlates, thyroid hormones, and blood pressure might contribute to recent suicide attempts in MDD patients with moderate-to-severe anxiety symptoms.https://doi.org/10.1186/s12888-025-06472-5Major depressive disorderModerate-to-severe anxietySuicideInfluencing factors |
| spellingShingle | Lina Ren Yeqing Dong Xiaojing Zhou Chuhao Zhang Jiajia Gao Lulu Li Xiao Zhang Min Zeng Guoshuai Luo Xiangyang Zhang The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study BMC Psychiatry Major depressive disorder Moderate-to-severe anxiety Suicide Influencing factors |
| title | The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study |
| title_full | The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study |
| title_fullStr | The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study |
| title_full_unstemmed | The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study |
| title_short | The incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate-to-severe anxiety: a large-scale cross-sectional study |
| title_sort | incidence and influencing factors of recent suicide attempts in major depressive disorder patients comorbid with moderate to severe anxiety a large scale cross sectional study |
| topic | Major depressive disorder Moderate-to-severe anxiety Suicide Influencing factors |
| url | https://doi.org/10.1186/s12888-025-06472-5 |
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