Protective effects of berbamine against arginase-1 deficiency-induced injury in human brain microvascular endothelial cells

Protective effects of berbamine against arginase-1 deficiency-induced injury in human brain microvascular endothelial cells

Endothelial cell dysfunction plays a crucial role in the early development of cerebral small vessel disease (CSVD). Arginase-1 (ARG1) is expressed in endothelial cells, and its deficiency may exacerbate cerebrovascular damage by increasing reactive oxygen species (ROS) production, thereby inducing e...

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Bibliographic Details
Main Authors: Xiaolan Wei, Weiwei Li, Zixuan Chen, Jintu Chen, Yun Chen, Jiangping Cai, Huasong Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
cerebral small vessel disease
arginase 1
arginine
berbamine
human brain microvascular endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1497973/full
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