The primate-specific Nedd4-1(NE) localizes to late endosomes in response to amino acids to suppress autophagy

The primate-specific Nedd4-1(NE) localizes to late endosomes in response to amino acids to suppress autophagy

Abstract The ubiquitin ligase Nedd4 (Nedd4-1), comprised of C2-WW(n)-HECT domains, regulates protein trafficking. We recently described a primate-specific Nedd4-1 splice isoform with an extended N-terminus replacing the C2 domain, called Nedd4-1(NE). Here, we show that while canonical Nedd4-1 is pri...

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Main Authors: G. Kefalas, A. Priya, A. Astori, A. Persaud, L. Jing, A. M. Sydor, H. H. Y. Yao, N. Warner, Y. Zhang, J. H. Brumell, A. M. Muise, S. Sari, H. C. Su, M. J. Lenardo, W. H. A. Kahr, B. Raught, D. Rotin
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57944-x
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https://doi.org/10.1038/s41467-025-57944-x

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