NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors

NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human γδ T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors

The interaction of the MHC class I-related chain molecules A and B (MICA and MICB) and UL-16 binding protein (ULBP) family members expressed on tumor cells with the corresponding NKG2D receptor triggers cytotoxic effector functions in NK cells and γδ T cells. However, as a mechanism of tumor immune...

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Bibliographic Details
Main Authors: Guranda Chitadze, Marcus Lettau, Stefanie Luecke, Ting Wang, Ottmar Janssen, Daniel Fürst, Joannis Mytilineos, Daniela Wesch, Hans-Heinrich Oberg, Janka Held-Feindt, Dieter Kabelitz
Format: Article
Language:English
Published: Taylor & Francis Group 2016-04-01
Series:OncoImmunology
Subjects:
Gamma delta T cells
glioblastoma
immunotherapy
NKG2D
T-cell receptor
ULBP2
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2015.1093276
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https://www.tandfonline.com/doi/10.1080/2162402X.2015.1093276

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