Epigallocatechin-gallate ameliorates polystyrene microplastics-induced oxido-inflammation and mitochondria-mediated apoptosis in testicular cells via modulation of Nrf2/HO-1, /mTOR/Atg-7, and Cx-43/NOX-1 levels

Epigallocatechin-gallate ameliorates polystyrene microplastics-induced oxido-inflammation and mitochondria-mediated apoptosis in testicular cells via modulation of Nrf2/HO-1, /mTOR/Atg-7, and Cx-43/NOX-1 levels

The study aimed to investigate the impact of Epigallocatechin-gallate (EGCG) on polystyrene microplastics (PS-MPs) induced reproductive anomalies in rats. To induce reproductive toxicity, PS-MPs were administered at a dose of 0.01 mg/kg/bw for several weeks. Following this, rats were treated with or...

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Main Authors: Mega Obukohwo Oyovwi, Emeka Williams Ugwuishi, Onoriode Andrew Udi, Adedeji David Atere, Arientare Rume Rotu, Emmanuel Igho Odokuma, Victor Oghenekparobo Emojevwe, Gideon Temitope Olowe, Eze Kingsley Nwangwa, Benneth Ben-Azu
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Epigallocatechin-gallate
Polystyrene microplastics
Oxidative stress
Spermatogenesis
Sex hormones
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424001158
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