Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy in endocrine therapy-resistant breast cancer

Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy in endocrine therapy-resistant breast cancer

Endocrine therapy has shown significant clinical efficacy in estrogen receptor alpha (ERα)-positive breast cancer management, but the emergence of therapy-resistant mutations significantly undermines treatment outcomes, frequently leading to disease progression and metastasis. Among these resistance...

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Main Authors: Mingshuang Wang, Liwei Pang, Yingjie Sun, Jingjing Han, Jiani Fan, Wenhui Shen, Xiaonan Hu, Bingqian Yang, Haoming Ning, Yanan Kong, Duo Li, Wenshan Zhao, Ranran Shi, Ling Ran, Yuanming Qi, Yahong Wu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
ESR1
Hotspot mutations
Neoepitopes
HLA-A2
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000806
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