High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells

High-resolution profile of neoantigen-specific TCR activation links moderate stimulation to increased resilience of engineered TCR-T cells

Abstract Neoantigen-specific T cell receptors (neoTCRs) promise safe, personalized anti-tumor immunotherapy. However, detailed assessment of neoTCR-characteristics affecting therapeutic efficacy is mostly missing. Previously, we identified diverse neoTCRs restricted to different neoantigens in a mel...

Full description

Saved in:
Bibliographic Details
Main Authors: Franziska Füchsl, Johannes Untch, Vladyslav Kavaka, Gabriela Zuleger, Sarah Braun, Antonia Schwanzer, Sebastian Jarosch, Carolin Vogelsang, Niklas de Andrade Krätzig, Dario Gosmann, Rupert Öllinger, Piero Giansanti, Michael Hiltensperger, Roland Rad, Dirk H. Busch, Eduardo Beltrán, Eva Bräunlein, Angela M. Krackhardt
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53911-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-024-53911-0

Similar Items