The astrocytic sigma-1 receptor constitutes in the fast antidepressant action of hypidone hydrochloride (YL-0919) in rodents

The astrocytic sigma-1 receptor constitutes in the fast antidepressant action of hypidone hydrochloride (YL-0919) in rodents

Introduction: There is increasing evidence that astrocytes are involved in the therapeutic action of antidepressants. The fast antidepressant YL-0919 may interact with activation of astrocytic sigma-1 receptors (sigma-1R).Methods: In this study, function of astrocytic sigma-1R in ventral hippocampus...

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Main Authors: Jin-Feng Li, Hai-Xia Chang, Jia-Ning Zhao, Jin-Hao Bao, Wei Dai, Yun-Feng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
astrocytes
sigma-1 receptor
antidepression
YL-0919
brain derived neurotrophic factor (BDNF)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1564851/full
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