41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

Background Acute myeloid leukemia (AML) is a hematopoietic malignancy which is biologically, phenotypically and genetically very heterogeneous. Outcome of patients with AML remains dismal, highlighting the need for improved, less toxic therapies. Chimeric antigen receptor T-cell (CART) immunotherapi...

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Main Authors: Pablo Menendez, Maria Castella, Pedro Marín, Alex Bataller, Jordi Esteve, Diego Sánchez Martínez, Francisco Gutiérrez Agüera, Heleia Roca Ho, Clara Bueno, Matteo Libero Baroni, Talia Velasco Hernandez, Rafael Diaz de la Guardia, Julio Castaño, Eduardo Anguita, Susana Vives, Josep Nomdedeu, Helene Lapillone, Anne E Bras, Vincent H J van der Velden, Jordi Junca, Binje Vick, Irmela Jeremias, Angel Lopez, Marc Sorigue
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000845.full
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