Synthesis, Biological Evaluation, and In Silico Characterization of Novel Imidazothiadiazole–Chalcone Hybrids as Multi-Target Enzyme Inhibitors

Synthesis, Biological Evaluation, and In Silico Characterization of Novel Imidazothiadiazole–Chalcone Hybrids as Multi-Target Enzyme Inhibitors

<b>Background/Objectives:</b> The need for dual-targeted enzyme inhibitors is critical in addressing complex diseases like Alzheimer’s and glaucoma. Imidazothiadiazole and chalcone moieties are known for diverse bioactivities. This study aimed to develop novel imidazothiadiazole–chalcone...

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Bibliographic Details
Main Authors: Hakan Alici, Senol Topuz, Kadir Demir, Parham Taslimi, Hakan Tahtaci
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
imidazothiadiazole
chalcone hybrids
carbonic anhydrase inhibitors
acetylcholinesterase inhibitors
butyrylcholinesterase inhibitors
molecular docking
Online Access:https://www.mdpi.com/1424-8247/18/7/962
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https://www.mdpi.com/1424-8247/18/7/962

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