Extracellular tau clearance is governed by its aggregation state and independent of microglial activation by LPS and IFN-γ

Extracellular tau clearance is governed by its aggregation state and independent of microglial activation by LPS and IFN-γ

Microglia are the tissue resident macrophages of the brain and their contribution to tau pathology progression remains to be fully understood. In this study, we developed a quantitative platform to elucidate the processing of extracellular tau within human induced pluripotent stem cell (iPSC)-derive...

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Bibliographic Details
Main Authors: Andrew Shultz, Anna Vincze, Todd T. Yau, Emma L. Poirier, Hannah Demanche, Jennifer N. Rauch
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neurobiology of Disease
Subjects:
Tau
Microglia
Tau spread
LRP1
Endo-lysosomal dysfunction
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002748
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