High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES
ObjectiveWe investigated the association between serum uric acid (SUA) levels and gallstone (GS) prevalence in adult women.MethodsParticipants' information were taken from the United States National Health and Nutrition Examination Survey (2017–2020). Logistic regression analysis and dose-respo...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1487974/full |
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| author | Guozheng Lv Guozheng Lv Decai Wang Decai Wang Yu Huang Ruizi Shi Chuan Qin Xi Chen Xintao Zeng Hua Luo Pei Yang Sirui Chen Jianjun Wang Jianjun Wang |
| author_facet | Guozheng Lv Guozheng Lv Decai Wang Decai Wang Yu Huang Ruizi Shi Chuan Qin Xi Chen Xintao Zeng Hua Luo Pei Yang Sirui Chen Jianjun Wang Jianjun Wang |
| author_sort | Guozheng Lv |
| collection | DOAJ |
| description | ObjectiveWe investigated the association between serum uric acid (SUA) levels and gallstone (GS) prevalence in adult women.MethodsParticipants' information were taken from the United States National Health and Nutrition Examination Survey (2017–2020). Logistic regression analysis and dose-response curve were used to assess the association between SUA levels and the prevalence of GS in adult women. Subgroup analyses were performed to investigate associations between SUA levels and age, ethnicity, body mass index, hypertension, and diabetes.ResultsA total of 600 participants self-reported a history of GS. After adjusting for confounding, the prevalence of GS in adult women increased by 14% for every 1 mg/dL increase in SUA (odds ratio [OR]: 1.14, 95% confidence interval [CI]: 1.06, 1.22). Testing SUA as a categorical variable for sensitivity analyses indicated a 1.6-fold increase in the prevalence of GS in tertile 3 (OR=1.60, 95% CI: 1.25, 2.04) compared to tertile 1. Dose-response curves showed a nonlinear correlation between SUA levels and the prevalence of GS. Subgroup analyses indicated that SUA level was associated with an increased prevalence of GS in most subgroups, although subtle differences existed.ConclusionSUA was positively and non-linearly associated with the prevalence of GS in adult females. Despite the inability to clarify the causal relationship between them, our results remain interesting. |
| format | Article |
| id | doaj-art-b088c5e5485342528079808dc7c66f77 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-b088c5e5485342528079808dc7c66f772025-01-17T06:51:05ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.14879741487974High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANESGuozheng Lv0Guozheng Lv1Decai Wang2Decai Wang3Yu Huang4Ruizi Shi5Chuan Qin6Xi Chen7Xintao Zeng8Hua Luo9Pei Yang10Sirui Chen11Jianjun Wang12Jianjun Wang13Department of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaTongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaNHC Key Laboratory of Nuclear Technology Medical Transformation, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaDepartment of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaNHC Key Laboratory of Nuclear Technology Medical Transformation, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, ChinaObjectiveWe investigated the association between serum uric acid (SUA) levels and gallstone (GS) prevalence in adult women.MethodsParticipants' information were taken from the United States National Health and Nutrition Examination Survey (2017–2020). Logistic regression analysis and dose-response curve were used to assess the association between SUA levels and the prevalence of GS in adult women. Subgroup analyses were performed to investigate associations between SUA levels and age, ethnicity, body mass index, hypertension, and diabetes.ResultsA total of 600 participants self-reported a history of GS. After adjusting for confounding, the prevalence of GS in adult women increased by 14% for every 1 mg/dL increase in SUA (odds ratio [OR]: 1.14, 95% confidence interval [CI]: 1.06, 1.22). Testing SUA as a categorical variable for sensitivity analyses indicated a 1.6-fold increase in the prevalence of GS in tertile 3 (OR=1.60, 95% CI: 1.25, 2.04) compared to tertile 1. Dose-response curves showed a nonlinear correlation between SUA levels and the prevalence of GS. Subgroup analyses indicated that SUA level was associated with an increased prevalence of GS in most subgroups, although subtle differences existed.ConclusionSUA was positively and non-linearly associated with the prevalence of GS in adult females. Despite the inability to clarify the causal relationship between them, our results remain interesting.https://www.frontiersin.org/articles/10.3389/fmed.2025.1487974/fullgallstonesserum uric acidNHANESwomencross-sectional study |
| spellingShingle | Guozheng Lv Guozheng Lv Decai Wang Decai Wang Yu Huang Ruizi Shi Chuan Qin Xi Chen Xintao Zeng Hua Luo Pei Yang Sirui Chen Jianjun Wang Jianjun Wang High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES Frontiers in Medicine gallstones serum uric acid NHANES women cross-sectional study |
| title | High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES |
| title_full | High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES |
| title_fullStr | High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES |
| title_full_unstemmed | High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES |
| title_short | High serum uric acid levels are associated with increased prevalence of gallstones in adult women: a cross-sectional study based on NHANES |
| title_sort | high serum uric acid levels are associated with increased prevalence of gallstones in adult women a cross sectional study based on nhanes |
| topic | gallstones serum uric acid NHANES women cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1487974/full |
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