Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature
Leiomyosarcoma (LMS) is an uncommon malignant spindle cell neoplasm of smooth muscles, accounting approximately 7% of soft tissue sarcoma. Primary LMS involving bone is an exceptional entity with very few cases described in the literature. The clinical, imaging, and pathological findings were analyz...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
|
| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801882 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849337568744701952 |
|---|---|
| author | Jitin Goyal Bineeta Parihar Nitin Agarwal Sulagna Manna Anila Sharma Sunil Kumar Puri |
| author_facet | Jitin Goyal Bineeta Parihar Nitin Agarwal Sulagna Manna Anila Sharma Sunil Kumar Puri |
| author_sort | Jitin Goyal |
| collection | DOAJ |
| description | Leiomyosarcoma (LMS) is an uncommon malignant spindle cell neoplasm of smooth muscles, accounting approximately 7% of soft tissue sarcoma. Primary LMS involving bone is an exceptional entity with very few cases described in the literature. The clinical, imaging, and pathological findings were analyzed retrospectively in three confirmed cases of primary LMS of bone. Pain and swelling were the patients' clinical symptoms. On imaging, LMS was often described as a solitary ill-defined lytic lesion with cortical breach depicted on radiograph or computed tomography (CT) scan. Magnetic resonance imaging (MRI) reveals a heterogeneous intermediate-hyperintense signal lesion on T2-weighted imaging (T2WI) with postcontrast enhancement. Histopathology reveals spindle cells arranged in fascicles with nuclear atypia and smooth muscle actin (SMA) positivity on immunohistochemistry (IHC)—consistent with diagnosis of LMS. The patients underwent surgical gross total resection with curative intent, followed by adjuvant chemotherapy or radiotherapy depending upon the stage and histological grade of LMS. On follow-up, the patients were disease free with no evidence of recurrence. |
| format | Article |
| id | doaj-art-b02ef4f15a7f44f9b698d41c543d2e08 |
| institution | Kabale University |
| issn | 0971-5851 0975-2129 |
| language | English |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-b02ef4f15a7f44f9b698d41c543d2e082025-08-20T03:44:39ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-212910.1055/s-0045-1801882Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of LiteratureJitin Goyal0https://orcid.org/0000-0001-9037-9031Bineeta Parihar1Nitin Agarwal2Sulagna Manna3Anila Sharma4Sunil Kumar Puri5Department of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, IndiaDepartment of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, IndiaDepartment of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, IndiaDepartment of Pathology; Rajiv Gandhi Cancer Institute and Research Centre, DelhiDepartment of Pathology; Rajiv Gandhi Cancer Institute and Research Centre, DelhiDepartment of Radiology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, IndiaLeiomyosarcoma (LMS) is an uncommon malignant spindle cell neoplasm of smooth muscles, accounting approximately 7% of soft tissue sarcoma. Primary LMS involving bone is an exceptional entity with very few cases described in the literature. The clinical, imaging, and pathological findings were analyzed retrospectively in three confirmed cases of primary LMS of bone. Pain and swelling were the patients' clinical symptoms. On imaging, LMS was often described as a solitary ill-defined lytic lesion with cortical breach depicted on radiograph or computed tomography (CT) scan. Magnetic resonance imaging (MRI) reveals a heterogeneous intermediate-hyperintense signal lesion on T2-weighted imaging (T2WI) with postcontrast enhancement. Histopathology reveals spindle cells arranged in fascicles with nuclear atypia and smooth muscle actin (SMA) positivity on immunohistochemistry (IHC)—consistent with diagnosis of LMS. The patients underwent surgical gross total resection with curative intent, followed by adjuvant chemotherapy or radiotherapy depending upon the stage and histological grade of LMS. On follow-up, the patients were disease free with no evidence of recurrence.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801882leiomyosarcomaimmunohistochemistryMRIPET-CTcase series |
| spellingShingle | Jitin Goyal Bineeta Parihar Nitin Agarwal Sulagna Manna Anila Sharma Sunil Kumar Puri Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature Indian Journal of Medical and Paediatric Oncology leiomyosarcoma immunohistochemistry MRI PET-CT case series |
| title | Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature |
| title_full | Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature |
| title_fullStr | Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature |
| title_full_unstemmed | Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature |
| title_short | Primary Leiomyosarcoma of Bone: A Rare Case Series with Review of Literature |
| title_sort | primary leiomyosarcoma of bone a rare case series with review of literature |
| topic | leiomyosarcoma immunohistochemistry MRI PET-CT case series |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801882 |
| work_keys_str_mv | AT jitingoyal primaryleiomyosarcomaofboneararecaseserieswithreviewofliterature AT bineetaparihar primaryleiomyosarcomaofboneararecaseserieswithreviewofliterature AT nitinagarwal primaryleiomyosarcomaofboneararecaseserieswithreviewofliterature AT sulagnamanna primaryleiomyosarcomaofboneararecaseserieswithreviewofliterature AT anilasharma primaryleiomyosarcomaofboneararecaseserieswithreviewofliterature AT sunilkumarpuri primaryleiomyosarcomaofboneararecaseserieswithreviewofliterature |