Cell therapy for scleroderma: progress in mesenchymal stem cells and CAR-T treatment

Cell therapy for scleroderma: progress in mesenchymal stem cells and CAR-T treatment

Cell therapy is an emerging strategy for precision treatment of scleroderma. This review systematically summarizes the research progress of mesenchymal stem cell (MSC) and chimeric antigen receptor T cell (CAR-T) therapies in scleroderma and discusses the challenges and future directions for develop...

Full description

Saved in:

Bibliographic Details
Main Authors:	Liting Chen, Rongshan Huang, Chaoshuo Huang, Guiming Nong, Yuanyuan Mo, Lvyin Ye, Kunhong Lin, Anping Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Medicine
Subjects:	scleroderma cell therapy mesenchymal stem cells mesenchymal stem cell exosomes chimeric antigen receptor T cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2024.1530887/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Exosomes derived from liver failure patients’ plasma stimulated mesenchymal stem cells alleviate acute liver failure
by: Zhuoran Wang, et al.
Published: (2025-02-01)

Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model
by: Fatemeh Kheradmand, et al.
Published: (2025-01-01)

Therapeutic effect of mesenchymal stem cell-derived exosome therapy for periodontal regeneration: a systematic review and meta-analysis of preclinical trials
by: Liping Zhou, et al.
Published: (2025-01-01)

Hydrogels empowered mesenchymal stem cells and the derived exosomes for regenerative medicine in age-related musculoskeletal diseases
by: Lixin Liu, et al.
Published: (2025-03-01)

Bone marrow mesenchymal stem cell‐derived exosomes improve renal fibrosis by reducing the polarisation of M1 and M2 macrophages through the activation of EP2 receptors
by: Yuqing Lu, et al.
Published: (2022-02-01)

MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS
by: Chunlai Yin, et al.
Published: (2025-02-01)

Functionality of endothelial cells differentiated from porcine epiblast stem cells, bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells
by: Yeon-Ji Lee, et al.
Published: (2024-12-01)

The Potential of Mesenchymal Stem Cell-Derived Exosomes to Treat Diabetes Mellitus
by: Ju-El Kim, et al.
Published: (2025-01-01)

Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy
by: Jianjing Lin, et al.
Published: (2025-01-01)

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis
by: Aliosha I. Figueroa-Valdés, et al.
Published: (2025-01-01)

Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis
by: Guo Zhonghua, et al.
Published: (2024-01-01)

Mesenchymal stem cells transplantation in the treatment of tendon disorders
by: Adrian Różycki, et al.
Published: (2025-01-01)

Mesenchymal stem cells derived exosomes: a new era in cardiac regeneration
by: Hossein Rayat Pisheh, et al.
Published: (2025-01-01)

The Effect of Exosomes Derived from Human Umbilical Cord Mesenchymal Stromal/Stem Cells on the Regeneration of Human Pulpectomized Tooth: A Case Report
by: Nazanin Jafari, et al.
Published: (2025-01-01)

Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p
by: Li T, et al.
Published: (2025-01-01)

Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review
by: Raghavendra B. Narasimha, et al.
Published: (2025-01-01)

Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency
by: Xiaofei Zhang, et al.
Published: (2025-04-01)

Therapeutic potential of mesenchymal stem cells and stem cell-derived extracellular vesicles in tuberculosis of various localizations: A review
by: Veronika V. Shumko, et al.
Published: (2024-10-01)

BCL-2 overexpression exosomes promote the proliferation and migration of mesenchymal stem cells in hypoxic environment for skin injury in rats
by: Ying Wang, et al.
Published: (2025-01-01)

Editorial: Perivascular niche and stem cell signaling in tooth
by: Takehito Ouchi, et al.
Published: (2025-01-01)

MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy
by: Jiabin Liang, et al.
Published: (2025-02-01)

Mesenchymal stem cell and exosome-based therapy for liver diseases: can it overcome conventional therapeutic inconsistencies?
by: Zahid Hussain
Published: (2025-01-01)

Induced mesenchymal stem cells generated from periodontal ligament fibroblast for regenerative therapy
by: Hemanathan Vembuli, et al.
Published: (2025-02-01)

Intrastromal autologous implantation of adipose derived adult stem cells for the management of established corneal scars
by: Jorge L. Alio del Barrio, et al.
Published: (2025-03-01)

Effect of mesenchymal stem cells on animal semen during storage
by: E. Yu. Zakirova, et al.
Published: (2023-12-01)

T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration
by: Haixing Wang, et al.
Published: (2025-03-01)

Effects of Adipose-tissue Derived Mesenchymal Stem Cells on PBMCs in Co-culture with HeLa Cell Line
by: Maryam Dorfaki, et al.
Published: (2024-04-01)

EFFICACY OF AMNIOTIC MEMBRANE MESENCHYMAL STEM CELL THERAPY FOR BURN WOUNDS: META-ANALYSIS STUDY
by: Bayu Fasi Bermani, et al.
Published: (2020-06-01)

Effect of Robusta Coffee Bean Extract as Immunoregulator on Dental Pulp Mesenchymal Stem Cells via Paracrine Pathway
by: Desi Sandra Sari, et al.
Published: (2025-02-01)

Effect of adipose mesenchymal stem cell-derived exosomes on allergic rhinitis in mice
by: Xiaojie Xu, et al.
Published: (2025-01-01)

Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis
by: Alberto González-González, et al.
Published: (2025-02-01)

CONSTANT MURLEY SCORE ON PATIENTS POST SUPRASPINATUS RECONSTRUCTION WITH MEMBRANE AMNION COMPOSITE AND FAT TISSUE ALLOGENIC MESENCHYMAL STEM CELL AUGMENTATION
by: Heri Suroto, et al.
Published: (2019-12-01)

The beneficial effects of thymoquinone on viability and differentiation of human adipose tissue-derived mesenchymal stem cells
by: Ahsen Erginsoy, et al.
Published: (2024-04-01)

Stem Cell Therapy for the Treatment of Amyotrophic Lateral Sclerosis: Comparison of the Efficacy of Mesenchymal Stem Cells, Neural Stem Cells, and Induced Pluripotent Stem Cells
by: Lauren Frawley, et al.
Published: (2024-12-01)

MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production
by: Xinrui Yang, et al.
Published: (2025-01-01)

Optimizing therapeutic outcomes: preconditioning strategies for MSC-derived extracellular vesicles
by: Yuqi Song, et al.
Published: (2025-02-01)

Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis
by: Damien Veret, et al.
Published: (2025-01-01)

Thyroid Hormone Activation Regulates the Crosstalk between Breast Cancer and Mesenchymal Stem Cells
by: Annarita Nappi, et al.
Published: (2025-01-01)

Tri-Lineage Differentiation Potential of Stem Cells from Human Exfoliated Deciduous Teeth - An In-vitro Study
by: Ratna Yumkham, et al.
Published: (2024-12-01)

Role of stem cells on motor function recovery in stroke patients: systematic review
by: Babita Raghuwanshi, et al.
Published: (2025-02-01)