Evaluation of the HumanMethylationEPIC v2.0 Bead Chip Using Low Quality and Quantity DNA Samples

Evaluation of the HumanMethylationEPIC v2.0 Bead Chip Using Low Quality and Quantity DNA Samples

Abstract Background The HumanMethylationEPIC v2.0 BeadChip (EPIC v2.0) microarray is a widely used tool for genome-wide DNA methylation (DNAm) analysis, designed for high-quality human DNA with a recommended input of 250 ng. However, in clinical and forensic settings, DNA samples may be of low quali...

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Main Authors: Brando Poggiali, Mikkel Eriksen Dupont, Marie-Louise Kampmann, Athina Vidaki, Vania Pereira, Claus Børsting, Jacob Tfelt-Hansen, Jeppe Dyrberg Andersen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Biological Procedures Online
Subjects:
DNA methylation
EPIC v2.0 microarray
Fragmented DNA
Low-input DNA
Clinical epigenetics
Forensic genetics
Online Access:https://doi.org/10.1186/s12575-025-00292-3
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https://doi.org/10.1186/s12575-025-00292-3

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