Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarction
Aim. To study the lipid-lowering and pleiotropic vasoprotective effects of atorvastatin depending on the achievement of the target low-density lipoprotein cholesterol (LDL-C) level in patients after ST-segment elevation myocardial infarction (STEMI) within 48-week follow-up period.Material and metho...
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| Format: | Article |
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«SILICEA-POLIGRAF» LLC
2022-08-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3157 |
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| author | L. I. Salyamova A. A. Khromova O. G. Kvasova K. N. Korenkova K. N. Polezhaeva N. A. Donetskaya K. I. Pavlenko |
| author_facet | L. I. Salyamova A. A. Khromova O. G. Kvasova K. N. Korenkova K. N. Polezhaeva N. A. Donetskaya K. I. Pavlenko |
| author_sort | L. I. Salyamova |
| collection | DOAJ |
| description | Aim. To study the lipid-lowering and pleiotropic vasoprotective effects of atorvastatin depending on the achievement of the target low-density lipoprotein cholesterol (LDL-C) level in patients after ST-segment elevation myocardial infarction (STEMI) within 48-week follow-up period.Material and methods. A total of 125 patients with STEMI, randomized to receive atorvastatin 40 or 80 mg per day for 48 weeks, were examined. On days 7-9, after 24, 48 weeks, we performed biochemical blood tests, echocardiography, as well as assessed the carotid arteries and endothelial function. The subjects were divided into the following groups: high-efficiency therapy (HET) — 41 patients who reached target LDL-C at control visits; moderate-efficiency therapy (MET) — 35 patients who achieved target LDL-C at one visit; low-efficiency therapy effective (LET) — 49 people who did not reach the target LDL-C. Differences were considered significant at p<0,05.Results. A decrease in detection rate of an elevated brain natriuretic peptide was found in HET group from 41,5 to 17% (p<0,01) and in MET group from 48,6 to 23% (p<0,01), while no changes in the LET were revealed. The glomerular filtration rate in the LET group decreased by 8% (p<0,01). In the HET group, a decrease in arterial elastance by 9,4%, intima-media thickness by 9,9%, a decrease in the frequency of a negative response and an increase in a positive response (p<0,05) were revealed.Conclusion. The results demonstrate the importance of achieving target LDL-C for the most favorable dynamics of brain natriuretic peptide, structural and functional characteristics of the arterial system. |
| format | Article |
| id | doaj-art-af36e22f72ca4acabe73c9fe44d0d2ef |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2022-08-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-af36e22f72ca4acabe73c9fe44d0d2ef2025-08-20T03:57:18Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252022-08-0121710.15829/1728-8800-2022-31572495Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarctionL. I. Salyamova0A. A. Khromova1O. G. Kvasova2K. N. Korenkova3K. N. Polezhaeva4N. A. Donetskaya5K. I. Pavlenko6Penza State UniversityPenza State UniversityPenza State UniversityPenza State UniversityPenza State UniversityPenza State UniversityPenza State UniversityAim. To study the lipid-lowering and pleiotropic vasoprotective effects of atorvastatin depending on the achievement of the target low-density lipoprotein cholesterol (LDL-C) level in patients after ST-segment elevation myocardial infarction (STEMI) within 48-week follow-up period.Material and methods. A total of 125 patients with STEMI, randomized to receive atorvastatin 40 or 80 mg per day for 48 weeks, were examined. On days 7-9, after 24, 48 weeks, we performed biochemical blood tests, echocardiography, as well as assessed the carotid arteries and endothelial function. The subjects were divided into the following groups: high-efficiency therapy (HET) — 41 patients who reached target LDL-C at control visits; moderate-efficiency therapy (MET) — 35 patients who achieved target LDL-C at one visit; low-efficiency therapy effective (LET) — 49 people who did not reach the target LDL-C. Differences were considered significant at p<0,05.Results. A decrease in detection rate of an elevated brain natriuretic peptide was found in HET group from 41,5 to 17% (p<0,01) and in MET group from 48,6 to 23% (p<0,01), while no changes in the LET were revealed. The glomerular filtration rate in the LET group decreased by 8% (p<0,01). In the HET group, a decrease in arterial elastance by 9,4%, intima-media thickness by 9,9%, a decrease in the frequency of a negative response and an increase in a positive response (p<0,05) were revealed.Conclusion. The results demonstrate the importance of achieving target LDL-C for the most favorable dynamics of brain natriuretic peptide, structural and functional characteristics of the arterial system.https://cardiovascular.elpub.ru/jour/article/view/3157myocardial infarctionatorvastatinpleiotropic effectscholesterollow-density lipoproteinsintima-media thicknessleft ventricular-arterial junctionendothelial function |
| spellingShingle | L. I. Salyamova A. A. Khromova O. G. Kvasova K. N. Korenkova K. N. Polezhaeva N. A. Donetskaya K. I. Pavlenko Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarction Кардиоваскулярная терапия и профилактика myocardial infarction atorvastatin pleiotropic effects cholesterol low-density lipoproteins intima-media thickness left ventricular-arterial junction endothelial function |
| title | Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarction |
| title_full | Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarction |
| title_fullStr | Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarction |
| title_full_unstemmed | Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarction |
| title_short | Pleiotropic vasoprotective effects of high-dose atorvastatin therapy in the context of achieving the target low-density lipoprotein cholesterol in patients after myocardial infarction |
| title_sort | pleiotropic vasoprotective effects of high dose atorvastatin therapy in the context of achieving the target low density lipoprotein cholesterol in patients after myocardial infarction |
| topic | myocardial infarction atorvastatin pleiotropic effects cholesterol low-density lipoproteins intima-media thickness left ventricular-arterial junction endothelial function |
| url | https://cardiovascular.elpub.ru/jour/article/view/3157 |
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