Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models

Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models

ABSTRACT Background Cancer‐associated cachexia (CAC) is a multifactorial syndrome characterised by progressive loss of muscle mass with limited Food and Drug Administration treatments. Although emerging evidence suggests that l‐leucine and β‐hydroxy‐β‐methyl butyrate (HMB) have potential for treatin...

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Main Authors: Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jin Ju Lim, Yeong Hoon Kang, Ji Wook Moon, Jeong Min Nam, Jeong Hyeon Kim, Donghun Kim, Jae Ho Shim, Hyeon Soo Kim
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Akt
alpha‐ketoisocaproate
cancer cachexia
FoxO3a
myostatin
protein turnover
Online Access:https://doi.org/10.1002/jcsm.70044
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https://doi.org/10.1002/jcsm.70044

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