Lysyl-tRNA synthetase 1 promotes atherogenesis via autophagy-related secretion and inflammation

Lysyl-tRNA synthetase 1 promotes atherogenesis via autophagy-related secretion and inflammation

Abstract Lysyl-tRNA synthetase 1 (KARS1), an aminoacyl-tRNA synthetase, was recently identified as a secreted pro-inflammatory agent. However, the vascular secretion and functions of KARS1 have not been characterized. This study investigated the secretion mechanisms of KARS1 and explored its functio...

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Main Authors: Kangmin Yun, Youngsik Seo, Yerim Oh, Sunghyen Kim, Hye Sun Maeng, Jin Gu Cho, Young Bae Son, Dong Ju Son, Kihwan Kwon, Sunghoon Kim, Hanjoong Jo, Heonyong Park
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
KARS1
Secretory autophagy
Laminar shear stress
Oscillatory shear stress
Vessel alteration
Cell apoptosis
Online Access:https://doi.org/10.1038/s41598-025-96046-y
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https://doi.org/10.1038/s41598-025-96046-y

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