Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review
In recent years, metal-organic frameworks (MOFs) have emerged as promising materials for biomedical applications, owing to their superior chemical versatility, unique textural properties and enhanced mechanical properties. However, their fast and uncontrolled degradation, together with the reduced b...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004745 |
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| author | Andrada-Ioana Damian-Buda Nariman Alipanah Faina Bider Orhan Sisman Zuzana Neščáková Aldo R. Boccaccini |
| author_facet | Andrada-Ioana Damian-Buda Nariman Alipanah Faina Bider Orhan Sisman Zuzana Neščáková Aldo R. Boccaccini |
| author_sort | Andrada-Ioana Damian-Buda |
| collection | DOAJ |
| description | In recent years, metal-organic frameworks (MOFs) have emerged as promising materials for biomedical applications, owing to their superior chemical versatility, unique textural properties and enhanced mechanical properties. However, their fast and uncontrolled degradation, together with the reduced bioactivity have restricted their clinical potential. To overcome these limitations, MOFs can be synergistically combined with other materials, such as bioactive glasses (BGs), known for their bioactivity and therapeutic ion releasing capabilities. Besides comparing MOFs and BGs, this review aims to present the latest achievements of different MOFs/BGs materials, with a particular focus on their complementary and synergistic properties. Key findings show that combining MOFs and BGs enables the development of composite materials with superior physicochemical and biological properties. Moreover, by choosing appropriate processing techniques, BGs and MOFs can be fabricated as scaffolds or coatings with fast mineralization ability and high corrosion resistance. In addition, incorporation of MOFs/BGs in hydrogels improves mechanical stability, bioactivity and antibacterial properties, while maintaining biocompatibility. The mechanisms behind the antibacterial properties, likely coming from the release of metal ions and organic ligands, are also discussed. Overall, this review highlights the current research directions and emerging trends in the synergistic use of MOFs and BGs for biomedical applications, which represents a novel strategy for developing a new family of advanced therapeutic materials. |
| format | Article |
| id | doaj-art-aea3ea750273443e987b4b01ac7111af |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-aea3ea750273443e987b4b01ac7111af2025-01-17T04:52:08ZengElsevierMaterials Today Bio2590-00642025-02-0130101413Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A reviewAndrada-Ioana Damian-Buda0Nariman Alipanah1Faina Bider2Orhan Sisman3Zuzana Neščáková4Aldo R. Boccaccini5Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen–Nuremberg, Cauerstraße 6, 91058, Erlangen, GermanyFunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček University of Trenčín, 911 50, Trenčín, SlovakiaInstitute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen–Nuremberg, Cauerstraße 6, 91058, Erlangen, GermanyFunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček University of Trenčín, 911 50, Trenčín, SlovakiaFunGlass – Centre for Functional and Surface Functionalized Glass, Alexander Dubček University of Trenčín, 911 50, Trenčín, Slovakia; Corresponding author.Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen–Nuremberg, Cauerstraße 6, 91058, Erlangen, Germany; Corresponding author.In recent years, metal-organic frameworks (MOFs) have emerged as promising materials for biomedical applications, owing to their superior chemical versatility, unique textural properties and enhanced mechanical properties. However, their fast and uncontrolled degradation, together with the reduced bioactivity have restricted their clinical potential. To overcome these limitations, MOFs can be synergistically combined with other materials, such as bioactive glasses (BGs), known for their bioactivity and therapeutic ion releasing capabilities. Besides comparing MOFs and BGs, this review aims to present the latest achievements of different MOFs/BGs materials, with a particular focus on their complementary and synergistic properties. Key findings show that combining MOFs and BGs enables the development of composite materials with superior physicochemical and biological properties. Moreover, by choosing appropriate processing techniques, BGs and MOFs can be fabricated as scaffolds or coatings with fast mineralization ability and high corrosion resistance. In addition, incorporation of MOFs/BGs in hydrogels improves mechanical stability, bioactivity and antibacterial properties, while maintaining biocompatibility. The mechanisms behind the antibacterial properties, likely coming from the release of metal ions and organic ligands, are also discussed. Overall, this review highlights the current research directions and emerging trends in the synergistic use of MOFs and BGs for biomedical applications, which represents a novel strategy for developing a new family of advanced therapeutic materials.http://www.sciencedirect.com/science/article/pii/S2590006424004745Metal-organic-frameworkBioactive glassTissue engineeringBiomedical applications |
| spellingShingle | Andrada-Ioana Damian-Buda Nariman Alipanah Faina Bider Orhan Sisman Zuzana Neščáková Aldo R. Boccaccini Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review Materials Today Bio Metal-organic-framework Bioactive glass Tissue engineering Biomedical applications |
| title | Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review |
| title_full | Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review |
| title_fullStr | Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review |
| title_full_unstemmed | Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review |
| title_short | Metal-organic framework (MOF)-bioactive glass (BG) systems for biomedical applications - A review |
| title_sort | metal organic framework mof bioactive glass bg systems for biomedical applications a review |
| topic | Metal-organic-framework Bioactive glass Tissue engineering Biomedical applications |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004745 |
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