High-temperature exposure during the early embryonic stage lowers core body temperature after growth via a hypothalamic Igfbp2-dependent mechanism

Abstract The mechanisms underlying individual differences in core body temperature (Tc) are unexplained by genetic factors and poorly understood. Here, we investigated whether the environmental temperature during early development affects postnatal Tc. Mouse embryos were cultured from pronuclear to...

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Bibliographic Details
Main Authors: Yuki Yoshimura, Tatsuo Watanabe, Kazuomi Nakamura, Akira Futatsugi, Katsuhiko Mikoshiba, Takeshi Y. Hiyama
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-024-80252-1
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