Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol

Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol

Abstract Background Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge. Methods We explore an approach that enables ferroptosis induction through external radiation. The key c...

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Main Authors: Jianwen Li, Shuyue Zhan, Wei Yang, He Zhang, Xinrui Ma, Fanghui Chen, Amy Li, Pakteema Tong, Fangchao Jiang, Zhengwei Cao, Ian Delahunty, Jiayi Wang, Yufei Wu, Zhi Liu, Zibo Li, Yong Teng, Libin Xu, Jin Xie
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Liposomes
7-dehydrocholesterol
Radiosensitizer
Lipid peroxidation
Ferroptosis
Online Access:https://doi.org/10.1186/s12951-025-03303-3
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https://doi.org/10.1186/s12951-025-03303-3

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