First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale
[18F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration. The initial goal of this study was to concurrently conduct PET imaging st...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-01-01
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| Series: | Molecular Imaging |
| Online Access: | http://dx.doi.org/10.1155/2023/8826977 |
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| author | Kimberly L. Desmond Anton Lindberg Armando Garcia Junchao Tong Michael B. Harkness Elena Dobrota Kelly Smart Carme Uribe Jeffrey H. Meyer Sylvain Houle Antonio P. Strafella Songye Li Yiyun Huang Neil Vasdev |
| author_facet | Kimberly L. Desmond Anton Lindberg Armando Garcia Junchao Tong Michael B. Harkness Elena Dobrota Kelly Smart Carme Uribe Jeffrey H. Meyer Sylvain Houle Antonio P. Strafella Songye Li Yiyun Huang Neil Vasdev |
| author_sort | Kimberly L. Desmond |
| collection | DOAJ |
| description | [18F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration. The initial goal of this study was to concurrently conduct PET imaging studies with [18F]SynVesT-1 at our laboratories. However, the data in the first two human PET studies had anomalous biodistribution despite the injected product meeting all specifications during the prerelease quality control protocols. Further investigation, including imaging in rats as well as proton and carbon 2D-NMR spectroscopic studies, led to the discovery that a derivative of the precursor had been received from the manufacturer. Hence, we report our investigation and the first-in-human study of [18F]SDM-4MP3, a structural variant of [18F]SynVesT-1, which does not have the requisite characteristics as a PET radiopharmaceutical for imaging SV2A in the central nervous system. |
| format | Article |
| id | doaj-art-ae6f880542624361ace3956843c9ef59 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-ae6f880542624361ace3956843c9ef592025-01-02T22:22:58ZengSAGE PublishingMolecular Imaging1536-01212023-01-01202310.1155/2023/8826977First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary TaleKimberly L. Desmond0Anton Lindberg1Armando Garcia2Junchao Tong3Michael B. Harkness4Elena Dobrota5Kelly Smart6Carme Uribe7Jeffrey H. Meyer8Sylvain Houle9Antonio P. Strafella10Songye Li11Yiyun Huang12Neil Vasdev13Azrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentreAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging CentrePET CenterPET CenterAzrieli Centre for Neuro-Radiochemistry & Brain Health Imaging Centre[18F]SynVesT-1 is a PET radiopharmaceutical that binds to the synaptic vesicle protein 2A (SV2A) and serves as a biomarker of synaptic density with widespread clinical research applications in psychiatry and neurodegeneration. The initial goal of this study was to concurrently conduct PET imaging studies with [18F]SynVesT-1 at our laboratories. However, the data in the first two human PET studies had anomalous biodistribution despite the injected product meeting all specifications during the prerelease quality control protocols. Further investigation, including imaging in rats as well as proton and carbon 2D-NMR spectroscopic studies, led to the discovery that a derivative of the precursor had been received from the manufacturer. Hence, we report our investigation and the first-in-human study of [18F]SDM-4MP3, a structural variant of [18F]SynVesT-1, which does not have the requisite characteristics as a PET radiopharmaceutical for imaging SV2A in the central nervous system.http://dx.doi.org/10.1155/2023/8826977 |
| spellingShingle | Kimberly L. Desmond Anton Lindberg Armando Garcia Junchao Tong Michael B. Harkness Elena Dobrota Kelly Smart Carme Uribe Jeffrey H. Meyer Sylvain Houle Antonio P. Strafella Songye Li Yiyun Huang Neil Vasdev First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale Molecular Imaging |
| title | First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale |
| title_full | First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale |
| title_fullStr | First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale |
| title_full_unstemmed | First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale |
| title_short | First-in-Human PET Imaging of [18F]SDM-4MP3: A Cautionary Tale |
| title_sort | first in human pet imaging of 18f sdm 4mp3 a cautionary tale |
| url | http://dx.doi.org/10.1155/2023/8826977 |
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