Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives
ABSTRACT Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to fo...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Online Access: | https://doi.org/10.1002/agt2.70081 |
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| author | Jie Zhong Juan C. Mareque‐Rivas Xinmiao Lan Yu‐Xiong Su |
| author_facet | Jie Zhong Juan C. Mareque‐Rivas Xinmiao Lan Yu‐Xiong Su |
| author_sort | Jie Zhong |
| collection | DOAJ |
| description | ABSTRACT Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to form organized assemblies through noncovalent interactions, affording versatile functional properties. By leveraging their unique structural characteristics and biological activities, innovative strategies can be developed to enhance the efficacy and safety of biomedical therapies. This review describes the recent advances in triterpenoids serving as (i) functional groups for aggregation‐induced emission, (ii) building blocks for self‐transportation and drug delivery, (iii) potential gelators for rational hydrogel design, and (iv) cholesterol alternatives for optimizing lipid‐based nanoparticles. The biomedical perspectives of triterpenoid‐based supramolecular assemblies and potential bottlenecks in clinical translation are also discussed, with the hope of offering insights into future research and biomedical applications. |
| format | Article |
| id | doaj-art-ae5c63feb5d840129ddd2dd76528e8cc |
| institution | Kabale University |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj-art-ae5c63feb5d840129ddd2dd76528e8cc2025-08-21T14:18:21ZengWileyAggregate2692-45602025-08-0168n/an/a10.1002/agt2.70081Supramolecular Assembly of Triterpenoids: Current State and Biomedical PerspectivesJie Zhong0Juan C. Mareque‐Rivas1Xinmiao Lan2Yu‐Xiong Su3Beijing Area Major Laboratory of Peptide and Small Molecular Drugs Engineering Research Center of Ministry of Education of China Beijing Laboratory of Biomedical Materials School of Pharmaceutical Sciences Capital Medical University Beijing ChinaDepartment of Chemistry and Centre for NanoHealth Swansea University Swansea UKBeijing Area Major Laboratory of Peptide and Small Molecular Drugs Engineering Research Center of Ministry of Education of China Beijing Laboratory of Biomedical Materials School of Pharmaceutical Sciences Capital Medical University Beijing ChinaDivision of Oral and Maxillofacial Surgery Faculty of Dentistry The University of Hong Kong Hong Kong SAR ChinaABSTRACT Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted the potential of triterpenoids to form organized assemblies through noncovalent interactions, affording versatile functional properties. By leveraging their unique structural characteristics and biological activities, innovative strategies can be developed to enhance the efficacy and safety of biomedical therapies. This review describes the recent advances in triterpenoids serving as (i) functional groups for aggregation‐induced emission, (ii) building blocks for self‐transportation and drug delivery, (iii) potential gelators for rational hydrogel design, and (iv) cholesterol alternatives for optimizing lipid‐based nanoparticles. The biomedical perspectives of triterpenoid‐based supramolecular assemblies and potential bottlenecks in clinical translation are also discussed, with the hope of offering insights into future research and biomedical applications.https://doi.org/10.1002/agt2.70081hydrogelsnanotheranosticsnatural productssupramolecular assemblytriterpenoids |
| spellingShingle | Jie Zhong Juan C. Mareque‐Rivas Xinmiao Lan Yu‐Xiong Su Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives Aggregate hydrogels nanotheranostics natural products supramolecular assembly triterpenoids |
| title | Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives |
| title_full | Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives |
| title_fullStr | Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives |
| title_full_unstemmed | Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives |
| title_short | Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives |
| title_sort | supramolecular assembly of triterpenoids current state and biomedical perspectives |
| topic | hydrogels nanotheranostics natural products supramolecular assembly triterpenoids |
| url | https://doi.org/10.1002/agt2.70081 |
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