Application of Theoretical Solubility Calculations and Thermal and Spectroscopic Measurements to Guide the Processing of Triamcinolone Acetonide by Hot-Melt Extrusion

Application of Theoretical Solubility Calculations and Thermal and Spectroscopic Measurements to Guide the Processing of Triamcinolone Acetonide by Hot-Melt Extrusion

<b>Background/Objectives</b>: Triamcinolone acetonide (TA), a poorly water-soluble corticosteroid, presents formulation challenges due to limited membrane permeability. This study aimed to identify suitable drug–polymer–plasticizer systems for TA using combined theoretical and experiment...

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Bibliographic Details
Main Authors: Pedro A. Granados, Idejan P. Gross, Patrícia Medeiros-Souza, Livia L. Sá-Barreto, Guilherme M. Gelfuso, Tais Gratieri, Marcilio Cunha-Filho
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
Hansen solubility parameters
hot-melt extrusion
miscibility
preformulation
thermal analysis
Fourier transform infrared spectroscopy
Online Access:https://www.mdpi.com/1999-4923/17/5/586
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