CFTR represses a PDX1 axis to govern pancreatic ductal cell fate

CFTR represses a PDX1 axis to govern pancreatic ductal cell fate

Summary: Inflammation, acinar atrophy, and ductal hyperplasia drive pancreatic remodeling in newborn cystic fibrosis (CF) ferrets lacking a functional cystic fibrosis conductance regulator (CFTR) channel. These changes are associated with a transient phase of glucose intolerance that involves islet...

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Main Authors: Pavana G. Rotti, Yaling Yi, Grace Gasser, Feng Yuan, Xingshen Sun, Idil Apak-Evans, Peipei Wu, Guangming Liu, Soon Choi, Rosie Reeves, Attilina E. Scioneaux, Yulong Zhang, Michael Winter, Bo Liang, Nathan Cunicelli, Aliye Uc, Andrew W. Norris, Lori Sussel, Kristen L. Wells, John F. Engelhardt
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Physiology
Molecular biology
Cell biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422402618X
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