Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications
Abstract Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and a well-defined structure. Hydrogels, structured with high water containing 3...
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| Format: | Article |
| Language: | English |
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Springer
2025-01-01
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| Series: | Discover Materials |
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| Online Access: | https://doi.org/10.1007/s43939-025-00178-x |
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| author | Md. Mahamudul Hasan Rumon Md. Sohanur Rahman Anwarul Azim Akib Md. Shafiuzzaman Sohag Md. Rakibul Alam Rakib Md. Abu Rayhan Khan Farzana Yesmin Md Salman Shakil Mohammad Mizanur Rahman Khan |
| author_facet | Md. Mahamudul Hasan Rumon Md. Sohanur Rahman Anwarul Azim Akib Md. Shafiuzzaman Sohag Md. Rakibul Alam Rakib Md. Abu Rayhan Khan Farzana Yesmin Md Salman Shakil Mohammad Mizanur Rahman Khan |
| author_sort | Md. Mahamudul Hasan Rumon |
| collection | DOAJ |
| description | Abstract Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and a well-defined structure. Hydrogels, structured with high water containing 3D-crosslinked polymeric networks, present a promising avenue in biomedical applications due to their close resemblance to natural tissues. However, their mechanical performance often falls short, limiting their clinical applications. Recent research has been focused on developing biocompatible hydrogel materials for therapeutic applications. Recent advancements have spurred researchers to develop biocompatible hydrogels having acceptable mechanical toughness. While it is now possible to tailor the mechanical properties of synthetic gels to mimic those of natural tissues, critical aspects such as biocompatibility and crosslinking strategies are frequently neglected. This review scrutinizes the structural and crosslinking techniques designed to improve the toughness of hydrogels, focusing especially on innovative efforts to integrate these enhancements into natural-based hydrogels. By thoroughly examining these methodologies, the review sheds light on the complexities of strengthening hydrogels for biomedical applications and will propose valuable insights for the development of next-generation tissue substitutes. |
| format | Article |
| id | doaj-art-adf25deb7bf044e5a97c7b22d26b3394 |
| institution | Kabale University |
| issn | 2730-7727 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Materials |
| spelling | doaj-art-adf25deb7bf044e5a97c7b22d26b33942025-01-12T12:44:06ZengSpringerDiscover Materials2730-77272025-01-015112910.1007/s43939-025-00178-xProgress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applicationsMd. Mahamudul Hasan Rumon0Md. Sohanur Rahman1Anwarul Azim Akib2Md. Shafiuzzaman Sohag3Md. Rakibul Alam Rakib4Md. Abu Rayhan Khan5Farzana Yesmin6Md Salman Shakil7Mohammad Mizanur Rahman Khan8Department of Chemistry, Bangladesh University of Engineering and TechnologyDepartment of Chemistry, Bangladesh University of Engineering and TechnologyDepartment of Chemistry, Bangladesh University of Engineering and TechnologyChemistry Discipline, Khulna UniversityDepartment of Physics, Carmichael CollegeChemistry Discipline, Khulna UniversityDepartment of Chemistry, Bangladesh University of Engineering and TechnologyDepartment of Mathematics and Natural Sciences, BRAC UniversityResearch Center for Green Energy Systems, Department of Mechanical Engineering, Gachon UniversityAbstract Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and a well-defined structure. Hydrogels, structured with high water containing 3D-crosslinked polymeric networks, present a promising avenue in biomedical applications due to their close resemblance to natural tissues. However, their mechanical performance often falls short, limiting their clinical applications. Recent research has been focused on developing biocompatible hydrogel materials for therapeutic applications. Recent advancements have spurred researchers to develop biocompatible hydrogels having acceptable mechanical toughness. While it is now possible to tailor the mechanical properties of synthetic gels to mimic those of natural tissues, critical aspects such as biocompatibility and crosslinking strategies are frequently neglected. This review scrutinizes the structural and crosslinking techniques designed to improve the toughness of hydrogels, focusing especially on innovative efforts to integrate these enhancements into natural-based hydrogels. By thoroughly examining these methodologies, the review sheds light on the complexities of strengthening hydrogels for biomedical applications and will propose valuable insights for the development of next-generation tissue substitutes.https://doi.org/10.1007/s43939-025-00178-xHydrogelsMechanical toughnessCrosslinking mechanismStimuli responsiveAnd biomedical applications |
| spellingShingle | Md. Mahamudul Hasan Rumon Md. Sohanur Rahman Anwarul Azim Akib Md. Shafiuzzaman Sohag Md. Rakibul Alam Rakib Md. Abu Rayhan Khan Farzana Yesmin Md Salman Shakil Mohammad Mizanur Rahman Khan Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications Discover Materials Hydrogels Mechanical toughness Crosslinking mechanism Stimuli responsive And biomedical applications |
| title | Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications |
| title_full | Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications |
| title_fullStr | Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications |
| title_full_unstemmed | Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications |
| title_short | Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications |
| title_sort | progress in hydrogel toughening addressing structural and crosslinking challenges for biomedical applications |
| topic | Hydrogels Mechanical toughness Crosslinking mechanism Stimuli responsive And biomedical applications |
| url | https://doi.org/10.1007/s43939-025-00178-x |
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