GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis

GPR55 in the tumor microenvironment of pancreatic cancer controls tumorigenesis

BackgroundThe G protein-coupled receptor 55 (GPR55) is part of an expanded endocannabinoid system (ECS), and plays a pro-tumorigenic role in different cancer models, including pancreatic cancer. Next to cancer cells, various cells of the immune tumor microenvironment (TME) express receptors of the E...

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Bibliographic Details
Main Authors: Dušica Ristić, Thomas Bärnthaler, Eva Gruden, Melanie Kienzl, Laura Danner, Karolina Herceg, Arailym Sarsembayeva, Julia Kargl, Rudolf Schicho
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
KPCY model
pancreatic cancer
GPR55
checkpoint inhibitors
anti-PD-1 antibody
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1513547/full
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