Activated melanocytes and senescent collagen fibers predict laser-treated melasma outcomes: An optical biopsy–based prospective cohort study

Activated melanocytes and senescent collagen fibers predict laser-treated melasma outcomes: An optical biopsy–based prospective cohort study

Background: Melasma Area and Severity Index (MASI) score only assesses the pigmentation rather than photoaging. Picosecond alexandrite laser (PAL) with diffractive lens array (DLA) can improve photoaging and has been approved for melasma treatment. Prediction for post-laser outcome is limited. Objec...

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Main Authors: Yen-Jen Wang, Chang-Cheng Chang, Yu-Hung Wu, Ling Huang, I-Ling Chen, Yu-Chang Shih, Hsing Cheng, Jia-Wei Shen, Meng-En Lu, Hsiu-Mei Chiang, Bor-Shyh Lin
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Basement membrane
Collagen
Melanocytes
Melasma
Optical coherence tomography
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100025001802
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