Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis

Abstract Psychological stress has profound impacts on the gastrointestinal tract via the brain‒gut axis. However, its effects on intestinal stem cells (ISCs) and the resulting implication for intestinal homeostasis remain poorly understood. Here, we observed a notable reduction in both the quantity...

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Bibliographic Details
Main Authors: Xiaole Sheng, Lanfei Jin, Zhengrong Yao, Jiaji Gu, Longtao Zhu, Andi Huang, Junxuan Peng, Xin Xu, Xiaolong Ge, Wei Zhou, Jinghao Sheng, Zhengping Xu, Rongpan Bai
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00796-y
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