Quantifying the behavioural relevance of hippocampal neurogenesis.
Few studies that examine the neurogenesis-behaviour relationship formally establish covariation between neurogenesis and behaviour or rule out competing explanations. The behavioural relevance of neurogenesis might therefore be overestimated if other mechanisms account for some, or even all, of the...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0113855 |
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| author | Stanley E Lazic Johannes Fuss Peter Gass |
| author_facet | Stanley E Lazic Johannes Fuss Peter Gass |
| author_sort | Stanley E Lazic |
| collection | DOAJ |
| description | Few studies that examine the neurogenesis-behaviour relationship formally establish covariation between neurogenesis and behaviour or rule out competing explanations. The behavioural relevance of neurogenesis might therefore be overestimated if other mechanisms account for some, or even all, of the experimental effects. A systematic review of the literature was conducted and the data reanalysed using causal mediation analysis, which can estimate the behavioural contribution of new hippocampal neurons separately from other mechanisms that might be operating. Results from eleven eligible individual studies were then combined in a meta-analysis to increase precision (representing data from 215 animals) and showed that neurogenesis made a negligible contribution to behaviour (standarised effect = 0.15; 95% CI = -0.04 to 0.34; p = 0.128); other mechanisms accounted for the majority of experimental effects (standardised effect = 1.06; 95% CI = 0.74 to 1.38; p = 1.7×10-11). |
| format | Article |
| id | doaj-art-ad8cb0fb5f2d4565b11a96e13f7e7e89 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-ad8cb0fb5f2d4565b11a96e13f7e7e892025-08-20T03:56:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11385510.1371/journal.pone.0113855Quantifying the behavioural relevance of hippocampal neurogenesis.Stanley E LazicJohannes FussPeter GassFew studies that examine the neurogenesis-behaviour relationship formally establish covariation between neurogenesis and behaviour or rule out competing explanations. The behavioural relevance of neurogenesis might therefore be overestimated if other mechanisms account for some, or even all, of the experimental effects. A systematic review of the literature was conducted and the data reanalysed using causal mediation analysis, which can estimate the behavioural contribution of new hippocampal neurons separately from other mechanisms that might be operating. Results from eleven eligible individual studies were then combined in a meta-analysis to increase precision (representing data from 215 animals) and showed that neurogenesis made a negligible contribution to behaviour (standarised effect = 0.15; 95% CI = -0.04 to 0.34; p = 0.128); other mechanisms accounted for the majority of experimental effects (standardised effect = 1.06; 95% CI = 0.74 to 1.38; p = 1.7×10-11).https://doi.org/10.1371/journal.pone.0113855 |
| spellingShingle | Stanley E Lazic Johannes Fuss Peter Gass Quantifying the behavioural relevance of hippocampal neurogenesis. PLoS ONE |
| title | Quantifying the behavioural relevance of hippocampal neurogenesis. |
| title_full | Quantifying the behavioural relevance of hippocampal neurogenesis. |
| title_fullStr | Quantifying the behavioural relevance of hippocampal neurogenesis. |
| title_full_unstemmed | Quantifying the behavioural relevance of hippocampal neurogenesis. |
| title_short | Quantifying the behavioural relevance of hippocampal neurogenesis. |
| title_sort | quantifying the behavioural relevance of hippocampal neurogenesis |
| url | https://doi.org/10.1371/journal.pone.0113855 |
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