Human responses to the DNA prime/chimpanzee adenovirus (ChAd63) boost vaccine identify CSP, AMA1 and TRAP MHC Class I-restricted epitopes.

Human responses to the DNA prime/chimpanzee adenovirus (ChAd63) boost vaccine identify CSP, AMA1 and TRAP MHC Class I-restricted epitopes.

<h4>Background</h4>A three-antigen DNA-prime/chimpanzee adenovirus 63 (ChAd63) boost vaccine containing pre-erythrocytic Plasmodium falciparum (Pf) circumsporozoite protein (CSP), Pf apical membrane antigen-1 (AMA1) and malaria multiple epitopes (ME) fused to Pf thrombospondin-related ad...

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Main Authors: Harini Ganeshan, Jun Huang, Maria Belmonte, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Santina Maiolatesi, Keith Limbach, Noelle Patterson, Marvin J Sklar, Lorraine Soisson, Judith E Epstein, Kimberly A Edgel, Bjoern Peters, Michael R Hollingdale, Eileen Villasante, Christopher A Duplessis, Martha Sedegah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0318098
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https://doi.org/10.1371/journal.pone.0318098

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