Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

Abstract Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in the co‐regulation of genes in two neurodegenerative diseases, late‐onset Alzheimer's disease (AD) and Huntington's disease...

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Main Authors: Manikandan Narayanan, Jimmy L Huynh, Kai Wang, Xia Yang, Seungyeul Yoo, Joshua McElwee, Bin Zhang, Chunsheng Zhang, John R Lamb, Tao Xie, Christine Suver, Cliona Molony, Stacey Melquist, Andrew D Johnson, Guoping Fan, David J Stone, Eric E Schadt, Patrizia Casaccia, Valur Emilsson, Jun Zhu
Format: Article
Language:English
Published: Springer Nature 2014-07-01
Series:Molecular Systems Biology
Subjects:
differential co‐expression
dysregulatory gene networks
epigenetic regulation of neural differentiation
network alignment
neurodegenerative diseases
Online Access:https://doi.org/10.15252/msb.20145304
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https://doi.org/10.15252/msb.20145304

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