(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway

(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway

IntroductionAs one of the most common complications of diabetes, diabetic cardiomyopathy (DCM) is the main cause of heart failure in patients with diabetes. However, the lack of effective treatments for DCM remains a clinical challenge. (Pro) renin receptor (PRR) is a member of renin angiotensin ald...

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Bibliographic Details
Main Authors: Shengnan Li, Jingjing Zhang, Yuewen Zhao, Li Kang, Haipeng Jie, Bo Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Pharmacology
Subjects:
(pro)renin receptor
diabetic cardiomyopathy
pyroptosis
NLRP3
AMPK (AMP-activated protein kinase)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1453647/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1453647/full

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